Peptide nucleic acids in materials science

Peptide nucleic acids in materials science

This review highlights the recent methods to prepare PNA-based materials through a combination of self-assembly and self-organization processes. The use of these methods allows easy and versatile preparation of structured hybrid materials showing specific recognition properties and unique physicochemical properties at the nano- and micro-scale levels displaying potential applications in several...

Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science

Nucleic acids: new life, new materials.

This article is part of the Nucleic acids: new life, new materials web‐themed issue Guest edited by: Mike Gait Medical Research Council, Cambridge, UK Ned Seeman New York University, USA David Liu Harvard University, USA Oliver Seitz Humboldt‐ Universität zu Berlin, Germany Makoto Komiyama University of Tsukuba, Japan Jason Micklefield University of Manchester, UK All articles in this issu...

Antisense properties of peptide nucleic acids.

PNA is a nucleic acid analog with an achiral polyamide backbone consisting of N-(2-aminoethyl)glycine units (figure 1). The purine or pyrimidine bases are linked to the each unit via a methylene carbonyl linker (1-3) to target the complementary nucleic acid (4). PNA binds to complementary RNA or DNA in a parallel or antiparallel orientation following the Watson-Crick base-pairing rules (5-7). T...

Magnetic peptide nucleic acids for DNA targeting.

A versatile synthetic platform for the efficient immobilization of PNAs on magnetic iron oxides, providing magnetic nanosensors for selective DNA recognition, is presented.